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High-quality crystals of human haematopoietic prostaglandin D synthase with novel inhibitors

Human haematopoietic prostaglandin D synthase (H-PGDS; EC 5.3.99.2) produces prostaglandin D(2), an allergic and inflammatory mediator, in mast cells and Th2 cells. H-PGDS has been crystallized with novel inhibitors with half-maximal inhibitory concentrations (IC(50)) in the low nanomolar range by t...

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Detalles Bibliográficos
Autores principales:	Takahashi, Sachiko, Tsurumura, Toshiharu, Aritake, Kosuke, Furubayashi, Naoki, Sato, Masaru, Yamanaka, Mari, Hirota, Erika, Sano, Satoshi, Kobayashi, Tomoyuki, Tanaka, Tetsuo, Inaka, Koji, Tanaka, Hiroaki, Urade, Yoshihiro
Formato:	Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2010
Materias:	Crystallization Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898477/ https://www.ncbi.nlm.nih.gov/pubmed/20606289 http://dx.doi.org/10.1107/S1744309110020828

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