Activation of IP(3) receptors by synthetic bisphosphate ligands

Ca(2+) release by d-myo-inositol 1,4,5-trisphosphate receptors (IP(3)Rs) is widely considered to require the vicinal 4,5-bisphosphate motif of IP(3), with P-5 and P-4 engaging the α and β domains of the binding site; using synthesis and mutagenesis we show that the adenine of synthetic glyconucleoti...

Descripción completa

Detalles Bibliográficos
Autores principales: Sureshan, Kana M., Riley, Andrew M., Rossi, Ana M., Tovey, Stephen C., Dedos, Skarlatos G., Taylor, Colin W., Potter, Barry V. L.
Formato: Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2009
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898634/
https://www.ncbi.nlm.nih.gov/pubmed/19240874
http://dx.doi.org/10.1039/b819328b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898634/
https://www.ncbi.nlm.nih.gov/pubmed/19240874
http://dx.doi.org/10.1039/b819328b

Ejemplares similares