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Activation of IP(3) receptors by synthetic bisphosphate ligands

Ca(2+) release by d-myo-inositol 1,4,5-trisphosphate receptors (IP(3)Rs) is widely considered to require the vicinal 4,5-bisphosphate motif of IP(3), with P-5 and P-4 engaging the α and β domains of the binding site; using synthesis and mutagenesis we show that the adenine of synthetic glyconucleoti...

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Detalles Bibliográficos
Autores principales:	Sureshan, Kana M., Riley, Andrew M., Rossi, Ana M., Tovey, Stephen C., Dedos, Skarlatos G., Taylor, Colin W., Potter, Barry V. L.
Formato:	Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2009
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898634/ https://www.ncbi.nlm.nih.gov/pubmed/19240874 http://dx.doi.org/10.1039/b819328b

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