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The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells
BACKGROUND: Regulator of chromosome condensation 1 (RCC1) is the guanine nucleotide exchange factor for Ran GTPase. Localised generation of Ran-GTP by RCC1 on chromatin is critical for nucleocytoplasmic transport, mitotic spindle assembly and nuclear envelope formation. Both the N-terminal tail of R...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898669/ https://www.ncbi.nlm.nih.gov/pubmed/20565941 http://dx.doi.org/10.1186/1471-2121-11-43 |