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Gemcitabine intercellular diffusion mediated by gap junctions: new implications for cancer therapy
BACKGROUND: Solid tumors are often poorly vascularized, with cells that can be 100 μm away from blood vessels. These distant cells get less oxygen and nutrients and are exposed to lower doses of chemotherapeutic agents. As gap junctions allow the passage of small molecules between cells, we tested t...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898703/ https://www.ncbi.nlm.nih.gov/pubmed/20537146 http://dx.doi.org/10.1186/1476-4598-9-141 |