Effects of ranolazine on wild-type and mutant hNa(v)1.7 channels and on DRG neuron excitability

BACKGROUND: A direct role of sodium channels in pain has recently been confirmed by establishing a monogenic link between SCN9A, the gene which encodes sodium channel Na(v)1.7, and pain disorders in humans, with gain-of-function mutations causing severe pain syndromes, and loss-of-function mutations...

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Detalles Bibliográficos
Autores principales: Estacion, Mark, Waxman, Stephen G, Dib-Hajj, Sulayman D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898769/
https://www.ncbi.nlm.nih.gov/pubmed/20529343
http://dx.doi.org/10.1186/1744-8069-6-35

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898769/
https://www.ncbi.nlm.nih.gov/pubmed/20529343
http://dx.doi.org/10.1186/1744-8069-6-35

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