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Effects of ranolazine on wild-type and mutant hNa(v)1.7 channels and on DRG neuron excitability
BACKGROUND: A direct role of sodium channels in pain has recently been confirmed by establishing a monogenic link between SCN9A, the gene which encodes sodium channel Na(v)1.7, and pain disorders in humans, with gain-of-function mutations causing severe pain syndromes, and loss-of-function mutations...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898769/ https://www.ncbi.nlm.nih.gov/pubmed/20529343 http://dx.doi.org/10.1186/1744-8069-6-35 |