Anticipating and blocking HIV-1 escape by second generation antiviral shRNAs

BACKGROUND: RNA interference (RNAi) is an evolutionary conserved gene silencing mechanism that mediates the sequence-specific breakdown of target mRNAs. RNAi can be used to inhibit HIV-1 replication by targeting the viral RNA genome. However, the error-prone replication machinery of HIV-1 can genera...

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Detalles Bibliográficos
Autores principales: Schopman, Nick CT, ter Brake, Olivier, Berkhout, Ben
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898777/
https://www.ncbi.nlm.nih.gov/pubmed/20529316
http://dx.doi.org/10.1186/1742-4690-7-52

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898777/
https://www.ncbi.nlm.nih.gov/pubmed/20529316
http://dx.doi.org/10.1186/1742-4690-7-52

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