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Anticipating and blocking HIV-1 escape by second generation antiviral shRNAs
BACKGROUND: RNA interference (RNAi) is an evolutionary conserved gene silencing mechanism that mediates the sequence-specific breakdown of target mRNAs. RNAi can be used to inhibit HIV-1 replication by targeting the viral RNA genome. However, the error-prone replication machinery of HIV-1 can genera...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898777/ https://www.ncbi.nlm.nih.gov/pubmed/20529316 http://dx.doi.org/10.1186/1742-4690-7-52 |