Mitochondrial DNA Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial DNA Mutator Mice

BACKGROUND: Aging results in a progressive loss of skeletal muscle, a condition known as sarcopenia. Mitochondrial DNA (mtDNA) mutations accumulate with aging in skeletal muscle and correlate with muscle loss, although no causal relationship has been established. METHODOLOGY/PRINCIPAL FINDINGS: We i...

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Detalles Bibliográficos
Autores principales: Hiona, Asimina, Sanz, Alberto, Kujoth, Gregory C., Pamplona, Reinald, Seo, Arnold Y., Hofer, Tim, Someya, Shinichi, Miyakawa, Takuya, Nakayama, Chie, Samhan-Arias, Alejandro K., Servais, Stephane, Barger, Jamie L., Portero-Otín, Manuel, Tanokura, Masaru, Prolla, Tomas A., Leeuwenburgh, Christiaan
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898813/
https://www.ncbi.nlm.nih.gov/pubmed/20628647
http://dx.doi.org/10.1371/journal.pone.0011468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898813/
https://www.ncbi.nlm.nih.gov/pubmed/20628647
http://dx.doi.org/10.1371/journal.pone.0011468

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