Active site plasticity revealed from the structure of the enterobacterial N-ribohydrolase RihA bound to a competitive inhibitor

BACKGROUND: Pyrimidine-preferring N-ribohydrolases (CU-NHs) are a class of Ca(2+)-dependent enzymes that catalyze the hydrolytic cleavage of the N-glycosidic bond in pyrimidine nucleosides. With the exception of few selected organisms, their physiological relevance in prokaryotes and eukaryotes is y...

Descripción completa

Detalles Bibliográficos
Autores principales: Garau, Gianpiero, Muzzolini, Laura, Tornaghi, Paola, Degano, Massimo
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898832/
https://www.ncbi.nlm.nih.gov/pubmed/20529317
http://dx.doi.org/10.1186/1472-6807-10-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898832/
https://www.ncbi.nlm.nih.gov/pubmed/20529317
http://dx.doi.org/10.1186/1472-6807-10-14

Ejemplares similares