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Active site plasticity revealed from the structure of the enterobacterial N-ribohydrolase RihA bound to a competitive inhibitor
BACKGROUND: Pyrimidine-preferring N-ribohydrolases (CU-NHs) are a class of Ca(2+)-dependent enzymes that catalyze the hydrolytic cleavage of the N-glycosidic bond in pyrimidine nucleosides. With the exception of few selected organisms, their physiological relevance in prokaryotes and eukaryotes is y...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898832/ https://www.ncbi.nlm.nih.gov/pubmed/20529317 http://dx.doi.org/10.1186/1472-6807-10-14 |