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The Human Gonadotropin Releasing Hormone Type I Receptor Is a Functional Intracellular GPCR Expressed on the Nuclear Membrane

The mammalian type I gonadotropin releasing hormone receptor (GnRH-R) is a structurally unique G protein-coupled receptor (GPCR) that lacks cytoplasmic tail sequences and displays inefficient plasma membrane expression (PME). Compared to its murine counterparts, the primate type I receptor is ineffi...

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Detalles Bibliográficos
Autores principales: Re, Michelle, Pampillo, Macarena, Savard, Martin, Dubuc, Céléna, McArdle, Craig A., Millar, Robert P., Conn, P. Michael, Gobeil, Fernand, Bhattacharya, Moshmi, Babwah, Andy V.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900216/
https://www.ncbi.nlm.nih.gov/pubmed/20628612
http://dx.doi.org/10.1371/journal.pone.0011489