Vaccinia Virus–Encoded Ribonucleotide Reductase Subunits Are Differentially Required for Replication and Pathogenesis

Ribonucleotide reductases (RRs) are evolutionarily-conserved enzymes that catalyze the rate-limiting step during dNTP synthesis in mammals. RR consists of both large (R1) and small (R2) subunits, which are both required for catalysis by the R1(2)R2(2) heterotetrameric complex. Poxviruses also encode...

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Detalles Bibliográficos
Autores principales: Gammon, Don B., Gowrishankar, Branawan, Duraffour, Sophie, Andrei, Graciela, Upton, Chris, Evans, David H.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900304/
https://www.ncbi.nlm.nih.gov/pubmed/20628573
http://dx.doi.org/10.1371/journal.ppat.1000984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900304/
https://www.ncbi.nlm.nih.gov/pubmed/20628573
http://dx.doi.org/10.1371/journal.ppat.1000984

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