Integration Preferences of Wildtype AAV-2 for Consensus Rep-Binding Sites at Numerous Loci in the Human Genome

Adeno-associated virus type 2 (AAV) is known to establish latency by preferential integration in human chromosome 19q13.42. The AAV non-structural protein Rep appears to target a site called AAVS1 by simultaneously binding to Rep-binding sites (RBS) present on the AAV genome and within AAVS1. In the...

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Detalles Bibliográficos
Autores principales: Hüser, Daniela, Gogol-Döring, Andreas, Lutter, Timo, Weger, Stefan, Winter, Kerstin, Hammer, Eva-Maria, Cathomen, Toni, Reinert, Knut, Heilbronn, Regine
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900306/
https://www.ncbi.nlm.nih.gov/pubmed/20628575
http://dx.doi.org/10.1371/journal.ppat.1000985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900306/
https://www.ncbi.nlm.nih.gov/pubmed/20628575
http://dx.doi.org/10.1371/journal.ppat.1000985

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