TL1A Selectively Enhances IL-12/IL-18-Induced NK Cell Cytotoxicity against NK-Resistant Tumor Targets

INTRODUCTION: TL1A (TNFSF15) augments IFN-γ production by IL-12/IL-18 responsive human T cells. Its ligand, death domain receptor 3 (DR3), is induced by activation on T and NK cells. Although IL-12/IL-18 induces DR3 expression on most NK cells, addition of TL1A minimally increases IFN-γ production....

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Detalles Bibliográficos
Autores principales: Heidemann, Stephanie C., Chavez, Valerie, Landers, Carol J., Kucharzik, Torsten, Prehn, John L., Targan, Stephan R.
Formato: Texto
Lenguaje:English
Publicado: Springer US 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900590/
https://www.ncbi.nlm.nih.gov/pubmed/20349123
http://dx.doi.org/10.1007/s10875-010-9382-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900590/
https://www.ncbi.nlm.nih.gov/pubmed/20349123
http://dx.doi.org/10.1007/s10875-010-9382-9

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