ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2

In mutant superoxide dismutase (SOD1)-linked amyotrophic lateral sclerosis (ALS), accumulation of misfolded mutant SOD1 in spinal cord mitochondria is thought to cause mitochondrial dysfunction. Whether mutant SOD1 is toxic per se or whether it damages the mitochondria through interactions with othe...

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Detalles Bibliográficos
Autores principales: Pedrini, Steve, Sau, Daniela, Guareschi, Stefania, Bogush, Marina, Brown, Robert H., Naniche, Nicole, Kia, Azadeh, Trotti, Davide, Pasinelli, Piera
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901139/
https://www.ncbi.nlm.nih.gov/pubmed/20460269
http://dx.doi.org/10.1093/hmg/ddq202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901139/
https://www.ncbi.nlm.nih.gov/pubmed/20460269
http://dx.doi.org/10.1093/hmg/ddq202

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