In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

Huntington's disease (HD) is a neurodegenerative disorder previously thought to be of primary neuronal origin, despite ubiquitous expression of mutant huntingtin (mHtt). We tested the hypothesis that mHtt expressed in astrocytes may contribute to the pathogenesis of HD. To better understand the...

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Detalles Bibliográficos
Autores principales: Faideau, Mathilde, Kim, Jinho, Cormier, Kerry, Gilmore, Richard, Welch, Mackenzie, Auregan, Gwennaelle, Dufour, Noelle, Guillermier, Martine, Brouillet, Emmanuel, Hantraye, Philippe, Déglon, Nicole, Ferrante, Robert J., Bonvento, Gilles
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901144/
https://www.ncbi.nlm.nih.gov/pubmed/20494921
http://dx.doi.org/10.1093/hmg/ddq212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901144/
https://www.ncbi.nlm.nih.gov/pubmed/20494921
http://dx.doi.org/10.1093/hmg/ddq212

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