Flavonoids activate pregnane × receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells

BACKGROUND: The expression of the drug-metabolizing enzyme cytochrome P450 3A4 (CYP3A4) is regulated by the pregnane × receptor (PXR), which is modulated by numerous signaling pathways, including the cyclin-dependent kinase (Cdk) pathway. Flavonoids, commonly consumed by humans as dietary constituen...

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Detalles Bibliográficos
Autores principales: Dong, Hanqing, Lin, Wenwei, Wu, Jing, Chen, Taosheng
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901217/
https://www.ncbi.nlm.nih.gov/pubmed/20553580
http://dx.doi.org/10.1186/1471-2091-11-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901217/
https://www.ncbi.nlm.nih.gov/pubmed/20553580
http://dx.doi.org/10.1186/1471-2091-11-23

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