Cargando…
Extracellular ATP and the P2X(7 )receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis
BACKGROUND: During pathology of the nervous system, increased extracellular ATP acts both as a cytotoxic factor and pro-inflammatory mediator through P2X(7 )receptors. In animal models of amyotrophic lateral sclerosis (ALS), astrocytes expressing superoxide dismutase 1 (SOD1(G93A)) mutations display...
Autores principales: | , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901222/ https://www.ncbi.nlm.nih.gov/pubmed/20534165 http://dx.doi.org/10.1186/1742-2094-7-33 |