Cargando…
Extracellular ATP and the P2X(7 )receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis
BACKGROUND: During pathology of the nervous system, increased extracellular ATP acts both as a cytotoxic factor and pro-inflammatory mediator through P2X(7 )receptors. In animal models of amyotrophic lateral sclerosis (ALS), astrocytes expressing superoxide dismutase 1 (SOD1(G93A)) mutations display...
Autores principales: | Gandelman, Mandi, Peluffo, Hugo, Beckman, Joseph S, Cassina, Patricia, Barbeito, Luis |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901222/ https://www.ncbi.nlm.nih.gov/pubmed/20534165 http://dx.doi.org/10.1186/1742-2094-7-33 |
Ejemplares similares
-
Modulation of Astrocytic Mitochondrial Function by Dichloroacetate Improves Survival and Motor Performance in Inherited Amyotrophic Lateral Sclerosis
por: Miquel, Ernesto, et al.
Publicado: (2012) -
Astrocyte-based cell therapy: new hope for amyotrophic lateral sclerosis patients?
por: Barbeito, Luis
Publicado: (2018) -
Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis
por: Allen, Scott P, et al.
Publicado: (2019) -
Axonal Dysfunction Precedes Motor Neuronal Death in Amyotrophic Lateral Sclerosis
por: Iwai, Yuta, et al.
Publicado: (2016) -
Extracellular Vesicles in Amyotrophic Lateral Sclerosis
por: McCluskey, Gavin, et al.
Publicado: (2022)