Chemotherapeutic drugs sensitize human renal cell carcinoma cells to ABT-737 by a mechanism involving the Noxa-dependent inactivation of Mcl-1 or A1

BACKGROUND: Human renal cell carcinoma (RCC) is very resistant to chemotherapy. ABT-737 is a novel inhibitor of anti-apoptotic proteins of the Bcl-2 family that has shown promise in various preclinical tumour models. RESULTS: We here report a strong over-additive pro-apoptotic effect of ABT-737 and...

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Detalles Bibliográficos
Autores principales: Zall, Henry, Weber, Arnim, Besch, Robert, Zantl, Niko, Häcker, Georg
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901261/
https://www.ncbi.nlm.nih.gov/pubmed/20576107
http://dx.doi.org/10.1186/1476-4598-9-164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901261/
https://www.ncbi.nlm.nih.gov/pubmed/20576107
http://dx.doi.org/10.1186/1476-4598-9-164

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