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Chemotherapeutic drugs sensitize human renal cell carcinoma cells to ABT-737 by a mechanism involving the Noxa-dependent inactivation of Mcl-1 or A1

BACKGROUND: Human renal cell carcinoma (RCC) is very resistant to chemotherapy. ABT-737 is a novel inhibitor of anti-apoptotic proteins of the Bcl-2 family that has shown promise in various preclinical tumour models. RESULTS: We here report a strong over-additive pro-apoptotic effect of ABT-737 and...

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Detalles Bibliográficos
Autores principales:	Zall, Henry, Weber, Arnim, Besch, Robert, Zantl, Niko, Häcker, Georg
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901261/ https://www.ncbi.nlm.nih.gov/pubmed/20576107 http://dx.doi.org/10.1186/1476-4598-9-164

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