Endoplasmic Reticulum Protein Targeting of Phospholamban: A Common Role for an N-Terminal Di-Arginine Motif in ER Retention?

BACKGROUND: Phospholamban (PLN) is an effective inhibitor of the sarco(endo)plasmic reticulum Ca(2+)-ATPase, which transports Ca(2+) into the SR lumen, leading to muscle relaxation. A mutation of PLN in which one of the di-arginine residues at positions 13 and 14 was deleted led to a severe, early o...

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Detalles Bibliográficos
Autores principales: Sharma, Parveen, Ignatchenko, Vladimir, Grace, Kevin, Ursprung, Claudia, Kislinger, Thomas, Gramolini, Anthony O.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901339/
https://www.ncbi.nlm.nih.gov/pubmed/20634894
http://dx.doi.org/10.1371/journal.pone.0011496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901339/
https://www.ncbi.nlm.nih.gov/pubmed/20634894
http://dx.doi.org/10.1371/journal.pone.0011496

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