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Anti-Inflammatory Activity of Chitooligosaccharides in Vivo

All the reports to date on the anti-inflammatory activity of chitooligosaccharides (COS) are mostly based on in vitro methods. In this work, the anti-inflammatory activity of two COS mixtures is characterized in vivo (using balb/c mice), following the carrageenan-induced paw edema method. This is a...

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Detalles Bibliográficos
Autores principales: Fernandes, João C., Spindola, Humberto, de Sousa, Vanessa, Santos-Silva, Alice, Pintado, Manuela E., Malcata, Francisco Xavier, Carvalho, João E.
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901823/
https://www.ncbi.nlm.nih.gov/pubmed/20631868
http://dx.doi.org/10.3390/md8061763
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author Fernandes, João C.
Spindola, Humberto
de Sousa, Vanessa
Santos-Silva, Alice
Pintado, Manuela E.
Malcata, Francisco Xavier
Carvalho, João E.
author_facet Fernandes, João C.
Spindola, Humberto
de Sousa, Vanessa
Santos-Silva, Alice
Pintado, Manuela E.
Malcata, Francisco Xavier
Carvalho, João E.
author_sort Fernandes, João C.
collection PubMed
description All the reports to date on the anti-inflammatory activity of chitooligosaccharides (COS) are mostly based on in vitro methods. In this work, the anti-inflammatory activity of two COS mixtures is characterized in vivo (using balb/c mice), following the carrageenan-induced paw edema method. This is a widely accepted animal model of acute inflammation to evaluate the anti-inflammatory effect of drugs. Our data suggest that COS possess anti-inflammatory activity, which is dependent on dose and, at higher doses, also on the molecular weight. A single dose of 500 mg/kg b.w. weight may be suitable to treat acute inflammation cases; however, further studies are needed to ascertain the effect upon longer inflammation periods as well as studies upon the bioavailability of these compounds.
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spelling pubmed-29018232010-07-14 Anti-Inflammatory Activity of Chitooligosaccharides in Vivo Fernandes, João C. Spindola, Humberto de Sousa, Vanessa Santos-Silva, Alice Pintado, Manuela E. Malcata, Francisco Xavier Carvalho, João E. Mar Drugs Communication All the reports to date on the anti-inflammatory activity of chitooligosaccharides (COS) are mostly based on in vitro methods. In this work, the anti-inflammatory activity of two COS mixtures is characterized in vivo (using balb/c mice), following the carrageenan-induced paw edema method. This is a widely accepted animal model of acute inflammation to evaluate the anti-inflammatory effect of drugs. Our data suggest that COS possess anti-inflammatory activity, which is dependent on dose and, at higher doses, also on the molecular weight. A single dose of 500 mg/kg b.w. weight may be suitable to treat acute inflammation cases; however, further studies are needed to ascertain the effect upon longer inflammation periods as well as studies upon the bioavailability of these compounds. Molecular Diversity Preservation International 2010-05-28 /pmc/articles/PMC2901823/ /pubmed/20631868 http://dx.doi.org/10.3390/md8061763 Text en © 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Fernandes, João C.
Spindola, Humberto
de Sousa, Vanessa
Santos-Silva, Alice
Pintado, Manuela E.
Malcata, Francisco Xavier
Carvalho, João E.
Anti-Inflammatory Activity of Chitooligosaccharides in Vivo
title Anti-Inflammatory Activity of Chitooligosaccharides in Vivo
title_full Anti-Inflammatory Activity of Chitooligosaccharides in Vivo
title_fullStr Anti-Inflammatory Activity of Chitooligosaccharides in Vivo
title_full_unstemmed Anti-Inflammatory Activity of Chitooligosaccharides in Vivo
title_short Anti-Inflammatory Activity of Chitooligosaccharides in Vivo
title_sort anti-inflammatory activity of chitooligosaccharides in vivo
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901823/
https://www.ncbi.nlm.nih.gov/pubmed/20631868
http://dx.doi.org/10.3390/md8061763
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