Splice-Site Mutations Cause Rrp6-Mediated Nuclear Retention of the Unspliced RNAs and Transcriptional Down-Regulation of the Splicing-Defective Genes

BACKGROUND: Eukaryotic cells have developed surveillance mechanisms to prevent the expression of aberrant transcripts. An early surveillance checkpoint acts at the transcription site and prevents the release of mRNAs that carry processing defects. The exosome subunit Rrp6 is required for this checkp...

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Detalles Bibliográficos
Autores principales: Eberle, Andrea B., Hessle, Viktoria, Helbig, Roger, Dantoft, Widad, Gimber, Niclas, Visa, Neus
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902512/
https://www.ncbi.nlm.nih.gov/pubmed/20634951
http://dx.doi.org/10.1371/journal.pone.0011540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902512/
https://www.ncbi.nlm.nih.gov/pubmed/20634951
http://dx.doi.org/10.1371/journal.pone.0011540

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