Impairment of Protein Trafficking upon Overexpression and Mutation of Optineurin

BACKGROUND: Glaucoma is a major blinding disease characterized by progressive loss of retinal ganglion cells (RGCs) and axons. Optineurin is one of the candidate genes identified so far. A mutation of Glu(50) to Lys (E50K) has been reported to be associated with a more progressive and severe disease...

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Detalles Bibliográficos
Autores principales: Park, BumChan, Ying, Hongyu, Shen, Xiang, Park, Jeong-Seok, Qiu, Ye, Shyam, Rajalekshmy, Yue, Beatrice Y. J. T.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902519/
https://www.ncbi.nlm.nih.gov/pubmed/20634958
http://dx.doi.org/10.1371/journal.pone.0011547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902519/
https://www.ncbi.nlm.nih.gov/pubmed/20634958
http://dx.doi.org/10.1371/journal.pone.0011547

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