Cargando…

Hsp90 as a Gatekeeper of Tumor Angiogenesis: Clinical Promise and Potential Pitfalls

Tumor vascularization is an essential modulator of early tumor growth, progression, and therapeutic outcome. Although antiangiogenic treatments appear promising, intrinsic and acquired tumor resistance contributes to treatment failure. Clinical inhibition of the molecular chaperone heat shock protei...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bohonowych, J. E., Gopal, U., Isaacs, J. S.
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2010
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902748/ https://www.ncbi.nlm.nih.gov/pubmed/20628489 http://dx.doi.org/10.1155/2010/412985

Ejemplares similares

Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation
por: Bohonowych, Jessica ES, et al.
Publicado: (2011)

A Novel Extracellular Hsp90 Mediated Co-Receptor Function for LRP1 Regulates EphA2 Dependent Glioblastoma Cell Invasion
por: Gopal, Udhayakumar, et al.
Publicado: (2011)

Molecular and functional crosstalk between extracellular Hsp90 and ephrin A1 signaling
por: Daoud, Abdelkader, et al.
Publicado: (2017)

Hsp90β promoted endothelial cell-dependent tumor angiogenesis in hepatocellular carcinoma
por: Meng, Jing, et al.
Publicado: (2017)

Hsp90 Inhibition: A Promising Therapeutic Approach for ARSACS
por: Nethisinghe, Suran, et al.
Publicado: (2021)

Induction of Hsp70 in tumor cells treated with inhibitors of the Hsp90 activity: A predictive marker and promising target for radiosensitization
por: Kudryavtsev, Vladimir A., et al.
Publicado: (2017)

Hsp90-stabilized MIF supports tumor progression via macrophage recruitment and angiogenesis in colorectal cancer
por: Klemke, Luisa, et al.
Publicado: (2021)

LANDSCAPE OF THE MITOCHONDRIAL Hsp90 METABOLOME IN TUMORS
por: Chae, Young Chan, et al.
Publicado: (2013)

HSP90 proteins in the scenario of tumor complexity
por: Rasola, Andrea
Publicado: (2017)

Heat Shock Protein 90 (Hsp90) and Hsp70 as Potential Therapeutic Targets in Autoimmune Skin Diseases
por: Tukaj, Stefan, et al.
Publicado: (2022)

The Promise and Pitfalls of Prophages
por: McKerral, Jody C., et al.
Publicado: (2023)

Potential role of heat shock protein 90 (Hsp90) in HIV uncoating
por: Joshi, Pheroze, et al.
Publicado: (2011)

The Hsp90 Inhibitor, Monorden, Is a Promising Lead Compound for the Development of Novel Fungicides
por: Nguyen, Hang T. T., et al.
Publicado: (2020)

Role of HSP90 in Cancer
por: Birbo, Bereket, et al.
Publicado: (2021)

The Potential of Hsp90 in Targeting Pathological Pathways in Cardiac Diseases
por: Roberts, Richard J., et al.
Publicado: (2021)

The Adaptive Potential of the Middle Domain of Yeast Hsp90
por: Cote-Hammarlof, Pamela A, et al.
Publicado: (2020)

Circulating heat shock protein 90 (Hsp90) and autoantibodies to Hsp90 are increased in patients with atopic dermatitis
por: Sitko, Krzysztof, et al.
Publicado: (2021)

Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90
por: Zhang, Guohua, et al.
Publicado: (2017)

Promise and pitfalls of the Immunochip
por: Cortes, Adrian, et al.
Publicado: (2011)

The Double-Edged Sword: Conserved Functions of Extracellular Hsp90 in Wound Healing and Cancer
por: Hance, Michael W., et al.
Publicado: (2014)

Y‐632 inhibits heat shock protein 90 (Hsp90) function by disrupting the interaction between Hsp90 and Hsp70/Hsp90 organizing protein, and exerts antitumor activity in vitro and in vivo
por: Wang, Wenqian, et al.
Publicado: (2016)

Differential expression of angiogenesis markers HSP70, HSP90, VEGF and pERK1/2 in both components of dedifferentiated chondrosarcomas
por: Schoedel, Karen, et al.
Publicado: (2021)

Targeting HSP90 for cancer therapy
por: Mahalingam, D, et al.
Publicado: (2009)

Corrigendum: The Hsp90 Inhibitor, Monorden, Is a Promising Lead Compound for the Development of Novel Fungicides
por: Nguyen, Hang T. T., et al.
Publicado: (2020)

Hsp-90 and the biology of nematodes
por: Him, Nik AIIN, et al.
Publicado: (2009)

Mechanisms of Hsp90 regulation
por: Prodromou, Chrisostomos
Publicado: (2016)

Regulatory Mechanisms of Hsp90
por: Prodromou, Chrisostomos
Publicado: (2017)

Inhibitors of HSP90 in melanoma
por: Mielczarek-Lewandowska, Aleksandra, et al.
Publicado: (2019)

Organismal Roles of Hsp90
por: van Oosten-Hawle, Patricija
Publicado: (2023)

The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases
por: Lackie, Rachel E., et al.
Publicado: (2017)

Senescence and senolytics in cardiovascular disease: Promise and potential pitfalls
por: Owens, W Andrew, et al.
Publicado: (2021)

The Distinct Assignments for Hsp90α and Hsp90β: More Than Skin Deep
por: Chang, Cheng, et al.
Publicado: (2023)

Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1
por: Park, Hye-Kyung, et al.
Publicado: (2020)

Therapeutic Potential of the Hsp90/Cdc37 Interaction in Neurodegenerative Diseases
por: Gracia, Liam, et al.
Publicado: (2019)

Traditional and Novel Mechanisms of Heat Shock Protein 90 (HSP90) Inhibition in Cancer Chemotherapy Including HSP90 Cleavage
por: Park, Sangkyu, et al.
Publicado: (2019)

Distinct Roles of Molecular Chaperones HSP90α and HSP90β in the Biogenesis of KCNQ4 Channels
por: Gao, Yanhong, et al.
Publicado: (2013)

HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation
por: Kijima, Toshiki, et al.
Publicado: (2018)

Modelling the Role of the Hsp70/Hsp90 System in the Maintenance of Protein Homeostasis
por: Proctor, Carole J., et al.
Publicado: (2011)

Synthesis and Evaluation of the Tumor Cell Growth Inhibitory Potential of New Putative HSP90 Inhibitors
por: Bizarro, Ana, et al.
Publicado: (2018)

The HSP90 inhibitor onalespib potentiates (177)Lu-DOTATATE therapy in neuroendocrine tumor cells
por: Lundsten, Sara, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3obg3bldk3ajodf0n2bqvrnvcm