Deoxygedunin, a Natural Product with Potent Neurotrophic Activity in Mice

Gedunin, a family of natural products from the Indian neem tree, possess a variety of biological activities. Here we report the discovery of deoxygedunin, which activates the mouse TrkB receptor and its downstream signaling cascades. Deoxygedunin is orally available and activates TrkB in mouse brain...

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Detalles Bibliográficos
Autores principales: Jang, Sung-Wuk, Liu, Xia, Chan, Chi Bun, France, Stefan A., Sayeed, Iqbal, Tang, Wenxue, Lin, Xi, Xiao, Ge, Andero, Raul, Chang, Qiang, Ressler, Kerry J., Ye, Keqiang
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903477/
https://www.ncbi.nlm.nih.gov/pubmed/20644624
http://dx.doi.org/10.1371/journal.pone.0011528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903477/
https://www.ncbi.nlm.nih.gov/pubmed/20644624
http://dx.doi.org/10.1371/journal.pone.0011528

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