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Purification of the CaaX-modified, dynamin-related large GTPase hGBP1 by coexpression with farnesyltransferase

Over a hundred proteins in eukaryotic cells carry a C-terminal CaaX box sequence, which targets them for posttranslational isoprenylation of the cysteine residue. This modification, catalyzed by either farnesyl or geranylgeranyl transferase, converts them into peripheral membrane proteins. Isoprenyl...

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Detalles Bibliográficos
Autores principales: Fres, Julia M., Müller, Stefan, Praefcke, Gerrit J. K.
Formato: Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903825/
https://www.ncbi.nlm.nih.gov/pubmed/20348589
http://dx.doi.org/10.1194/jlr.D005397