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The TLR4/TRIF-Mediated Activation of NLRP3 Inflammasome Underlies Endotoxin-Induced Liver Injury in Mice
Administration of heat-killed Propionibacterium acnes renders mice highly susceptible to LPS. After LPS challenge P. acnes-primed mice promptly show hypothermia, hypercoagulation (disseminated intravascular coagulation), elevation of serum proinflammatory cytokine levels, and high mortality. The sur...
Autores principales: | Tsutsui, Hiroko, Imamura, Michiko, Fujimoto, Jiro, Nakanishi, Kenji |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904443/ https://www.ncbi.nlm.nih.gov/pubmed/20634907 http://dx.doi.org/10.1155/2010/641865 |
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