PXR-mediated induction of P-glycoprotein by anticancer drugs in a human colon adenocarcinoma-derived cell line

PURPOSE: The development of multidrug resistance (MDR) is one of the major limitations in the treatment of cancer. Induction of P-glycoprotein (Pgp) has been regarded as one of the main mechanisms underlying anticancer drug-induced MDR. Since the induction of Pgp is (in part) regulated by the pregna...

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Detalles Bibliográficos
Autores principales: Harmsen, Stefan, Meijerman, I., Febus, C. L., Maas-Bakker, R. F., Beijnen, J. H., Schellens, J. H. M.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904455/
https://www.ncbi.nlm.nih.gov/pubmed/20041327
http://dx.doi.org/10.1007/s00280-009-1221-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904455/
https://www.ncbi.nlm.nih.gov/pubmed/20041327
http://dx.doi.org/10.1007/s00280-009-1221-4

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