A Screen for Kinetochore-Microtubule Interaction Inhibitors Identifies Novel Antitubulin Compounds

BACKGROUND: Protein assemblies named kinetochores bind sister chromatids to the mitotic spindle and orchestrate sister chromatid segregation. Interference with kinetochore activity triggers a spindle checkpoint mediated arrest in mitosis, which frequently ends in cell death. We set out to identify s...

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Detalles Bibliográficos
Autores principales: Screpanti, Emanuela, Santaguida, Stefano, Nguyen, Tam, Silvestri, Romano, Gussio, Rick, Musacchio, Andrea, Hamel, Ernest, De Wulf, Peter
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904697/
https://www.ncbi.nlm.nih.gov/pubmed/20657644
http://dx.doi.org/10.1371/journal.pone.0011603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904697/
https://www.ncbi.nlm.nih.gov/pubmed/20657644
http://dx.doi.org/10.1371/journal.pone.0011603

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