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A Screen for Kinetochore-Microtubule Interaction Inhibitors Identifies Novel Antitubulin Compounds
BACKGROUND: Protein assemblies named kinetochores bind sister chromatids to the mitotic spindle and orchestrate sister chromatid segregation. Interference with kinetochore activity triggers a spindle checkpoint mediated arrest in mitosis, which frequently ends in cell death. We set out to identify s...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904697/ https://www.ncbi.nlm.nih.gov/pubmed/20657644 http://dx.doi.org/10.1371/journal.pone.0011603 |