Cargando…

DCB-3503, a Tylophorine Analog, Inhibits Protein Synthesis through a Novel Mechanism

BACKGROUND: DCB-3503, a tylophorine analog, inhibits the growth of PANC-1 (human pancreatic ductal cancer cell line) and HepG2 (human hepatocellular cancer cell line) tumor xenografts in nude mice. The inhibition of growth leads to cancer cell differentiation instead of cell death. However, the mech...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Ying, Gao, Wenli, Svitkin, Yuri V., Chen, Annie Pei-Chun, Cheng, Yung-Chi
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904705/ https://www.ncbi.nlm.nih.gov/pubmed/20657652 http://dx.doi.org/10.1371/journal.pone.0011607

Ejemplares similares

Tylophorine Analog DCB-3503 Inhibited Cyclin D1 Translation through Allosteric Regulation of Heat Shock Cognate Protein 70
por: Wang, Ying, et al.
Publicado: (2016)

Cryptopleurine Analogs with Modification of E Ring Exhibit Different Mechanism to Rac-Cryptopleurine and Tylophorine
por: Wang, Ying, et al.
Publicado: (2012)

Tylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication
por: Wang, Ying, et al.
Publicado: (2017)

Tylophorine: Sources, Properties, Applications and Biotechnological Production
por: Cyriac, Angeline, et al.
Publicado: (2020)

3503 Restrictive feeding and excessive hunger in young children with obesity: A case series
por: Eagleton, Sally Grace, et al.
Publicado: (2019)

Adaptive Mechanisms of Shewanella xiamenensis DCB 2-1 Metallophilicity
por: Abuladze, Marina, et al.
Publicado: (2023)

Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents
por: Omran, Ziad, et al.
Publicado: (2021)

Small extracellular vesicles in combination with sleep-related circRNA3503: A targeted therapeutic agent with injectable thermosensitive hydrogel to prevent osteoarthritis
por: Tao, Shi-Cong, et al.
Publicado: (2021)

Inhibition of SARS-CoV-2 by Highly Potent Broad-Spectrum Anti-Coronaviral Tylophorine-Based Derivatives
por: Yang, Cheng-Wei, et al.
Publicado: (2020)

The Synergistic Inhibition of Coronavirus Replication and Induced Cytokine Production by Ciclesonide and the Tylophorine-Based Compound Dbq33b
por: Lee, Yue-Zhi, et al.
Publicado: (2022)

A Study on the Susceptibility to SCC of 7050 Aluminum Alloy by DCB Specimens
por: Qi, Xing, et al.
Publicado: (2016)

Experimental and numerical study on DCB specimens bonded with similar and dissimilar materials
por: Ma, Mingze, et al.
Publicado: (2022)

Impact of Scoring Balloon Angioplasty on Lesion Preparation for DCB Treatment of Coronary Lesions
por: Shin, Eun-Seok, et al.
Publicado: (2023)

Benzoindolizidine Alkaloids Tylophorine and Lycorine and Their Analogues with Antiviral, Anti-Inflammatory, and Anticancer Properties: Promises and Challenges
por: Di Sotto, Antonella, et al.
Publicado: (2023)

Discovery and Nanosized Preparations of (S,R)-Tylophorine Malate as Novel anti-SARS-CoV-2 Agents
por: Wang, Ziwen, et al.
Publicado: (2021)

A Small Range Six-Axis Accelerometer Designed with High Sensitivity DCB Elastic Element
por: Sun, Zhibo, et al.
Publicado: (2016)

Back to the future: DCB use instead of DES for the treatment of complex, native coronary artery disease
por: Cortese, Bernardo, et al.
Publicado: (2021)

Proteome adaptations of the organohalide-respiring Desulfitobacterium hafniense strain DCB-2 to various energy metabolisms
por: Willemin, Mathilde Stéphanie, et al.
Publicado: (2023)

Structure of the cobalamin-binding protein of a putative O-demethylase from Desulfitobacterium hafniense DCB-2
por: Sjuts, Hanno, et al.
Publicado: (2013)

Genome sequence of Desulfitobacterium hafniense DCB-2, a Gram-positive anaerobe capable of dehalogenation and metal reduction
por: Kim, Sang-Hoon, et al.
Publicado: (2012)

DCB dissolution of iron oxides in aeolian dust deposits controlled by particle size rather than mineral species
por: Yang, Qianqian, et al.
Publicado: (2022)

Correction: Lee et al. The Synergistic Inhibition of Coronavirus Replication and Induced Cytokine Production by Ciclesonide and the Tylophorine-Based Compound Dbq33b. Pharmaceutics 2022, 14, 1511
por: Lee, Yue-Zhi, et al.
Publicado: (2023)

Tylophorine Abrogates G2/M Arrest Induced by Doxorubicine and Promotes Increased Apoptosis in T47D Breast Cancer Cells
por: Pratama, Nofran Putra, et al.
Publicado: (2018)

N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density
por: Svitkin, Yuri V., et al.
Publicado: (2017)

Long-term safety of paclitaxel drug-coated balloon-only angioplasty for de novo coronary artery disease: the SPARTAN DCB study
por: Merinopoulos, Ioannis, et al.
Publicado: (2020)

Antiangiogenic Activity of n-hexane Insoluble Fraction and Its Tylophorine Component from Ficus septica Leaves in Chicken Chorioallantoic Membrane Induced by bFGF
por: Nurhasanah, Devika, et al.
Publicado: (2023)

Response to pre-dilatation with POBA can predict target lesion revascularization after DCB angioplasty for de novo small coronary artery lesions
por: Takamura, Taka-aki, et al.
Publicado: (2022)

Development of a Unified Specimen for Adhesive Characterisation—Part 1: Numerical Study on the Mode I (mDCB) and II (ELS) Fracture Components
por: Correia, Daniel S., et al.
Publicado: (2023)

Synthesis of Azido-Globo H Analogs for Immunogenicity Evaluation
por: Chen, Chiang-Yun, et al.
Publicado: (2021)

Membrane-dependent relief of translation elongation arrest on pseudouridine- and N(1)-methyl-pseudouridine-modified mRNAs
por: Svitkin, Yuri V, et al.
Publicado: (2021)

Tylophorine, a phenanthraindolizidine alkaloid isolated from Tylophora indica exerts antiangiogenic and antitumor activity by targeting vascular endothelial growth factor receptor 2–mediated angiogenesis
por: Saraswati, Sarita, et al.
Publicado: (2013)

Design and synthesis of novel cytotoxic fluoroquinolone analogs through topoisomerase inhibition, cell cycle arrest, and apoptosis
por: Elanany, Mohamed A., et al.
Publicado: (2023)

Draft Genome Sequence of a Dissimilatory U(VI)-Reducing Bacterium, Shewanella xiamenensis Strain DCB2-1, Isolated from Nitrate- and Radionuclide-Contaminated Groundwater in Russia
por: Grouzdev, Denis S., et al.
Publicado: (2018)

Rationale and design for comparison of non-compliant balloon with drug-coating balloon angioplasty for side branch after provisional stenting for patients with true coronary bifurcation lesions: a prospective, multicentre and randomised DCB-BIF trial
por: Gao, Xiao-Fei, et al.
Publicado: (2022)

Enzymatic Synthesis of Variediene Analogs
por: Liang, Lin‐Fu, et al.
Publicado: (2022)

Unique translation initiation of mRNAs-containing TISU element
por: Elfakess, Rofa, et al.
Publicado: (2011)

Association of tumour and stroma PD-1, PD-L1, CD3, CD4 and CD8 expression with DCB and OS to nivolumab treatment in NSCLC patients pre-treated with chemotherapy
por: Niemeijer, Anna-Larissa Nadia, et al.
Publicado: (2020)

DCB combined with provisional DES implantation in the treatment of De Novo Medina 0,1,0 or 0,0,1 left main coronary bifurcation lesions: A proof-of-concept study
por: Erdoğan, Emrah, et al.
Publicado: (2022)

Synthesis and Structure-Activity Relationships of Fenbufen Amide Analogs
por: Lin, Kun-I, et al.
Publicado: (2010)

Lactones in the Synthesis of Prostaglandins and Prostaglandin Analogs
por: Tănase, Constantin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_8minkdba73uod9cp3rut6f9rp8