Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo

Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal connection to Alzheimer's disease, including both protective and detri...

Descripción completa

Detalles Bibliográficos
Autores principales: Khurana, Vikram, Elson-Schwab, Ilan, Fulga, Tudor A., Sharp, Katherine A., Loewen, Carin A., Mulkearns, Erin, Tyynelä, Jaana, Scherzer, Clemens R., Feany, Mel B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904797/
https://www.ncbi.nlm.nih.gov/pubmed/20664788
http://dx.doi.org/10.1371/journal.pgen.1001026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904797/
https://www.ncbi.nlm.nih.gov/pubmed/20664788
http://dx.doi.org/10.1371/journal.pgen.1001026

Ejemplares similares