Betulinic acid induces apoptosis and inhibits hedgehog signalling in rhabdomyosarcoma

BACKGROUND: Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in childhood with the ability to resist apoptosis by the activation of survival promoting and anti-apoptotic proteins. METHODS: Efficacy of the apoptosis-inducing agent betulinic acid (BA) was determined in RMS cell cultures a...

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Detalles Bibliográficos
Autores principales: Eichenmüller, M, Hemmerlein, B, von Schweinitz, D, Kappler, R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905279/
https://www.ncbi.nlm.nih.gov/pubmed/20517313
http://dx.doi.org/10.1038/sj.bjc.6605715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905279/
https://www.ncbi.nlm.nih.gov/pubmed/20517313
http://dx.doi.org/10.1038/sj.bjc.6605715

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