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Betulinic acid induces apoptosis and inhibits hedgehog signalling in rhabdomyosarcoma

BACKGROUND: Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in childhood with the ability to resist apoptosis by the activation of survival promoting and anti-apoptotic proteins. METHODS: Efficacy of the apoptosis-inducing agent betulinic acid (BA) was determined in RMS cell cultures a...

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Detalles Bibliográficos
Autores principales:	Eichenmüller, M, Hemmerlein, B, von Schweinitz, D, Kappler, R
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2010
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905279/ https://www.ncbi.nlm.nih.gov/pubmed/20517313 http://dx.doi.org/10.1038/sj.bjc.6605715

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