Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomide

BACKGROUND: The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) can cause resistance to the alkylating drug temozolomide (TMZ). The purpose of this study was to determine the relationship between the MGMT status, determined by means of several techniques and methods, and the cytot...

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Detalles Bibliográficos
Autores principales: van Nifterik, K A, van den Berg, J, van der Meide, W F, Ameziane, N, Wedekind, L E, Steenbergen, R D M, Leenstra, S, Lafleur, M V M, Slotman, B J, Stalpers, L J A, Sminia, P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905289/
https://www.ncbi.nlm.nih.gov/pubmed/20517307
http://dx.doi.org/10.1038/sj.bjc.6605712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905289/
https://www.ncbi.nlm.nih.gov/pubmed/20517307
http://dx.doi.org/10.1038/sj.bjc.6605712

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