Transgenic Expression of the Amyloid-β Precursor Protein-Intracellular Domain Does Not Induce Alzheimer's Disease–Like Traits In Vivo

BACKGROUND: Regulated intramembranous proteolysis of the amyloid-β precursor protein by the γ-secretase yields amyloid-β, which is the major component of the amyloid plaques found in Alzheimer's disease (AD), and the APP intracellular domain (AID). In vitro studies have involved AID in apoptosi...

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Detalles Bibliográficos
Autores principales: Giliberto, Luca, d'Abramo, Cristina, Acker, Christopher Michael, Davies, Peter, D'Adamio, Luciano
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905372/
https://www.ncbi.nlm.nih.gov/pubmed/20661273
http://dx.doi.org/10.1371/journal.pone.0011609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905372/
https://www.ncbi.nlm.nih.gov/pubmed/20661273
http://dx.doi.org/10.1371/journal.pone.0011609

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