Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome

BACKGROUND: Down syndrome (DS) individuals suffer mental retardation with further cognitive decline and early onset Alzheimer's disease. METHODOLOGY/PRINCIPAL FINDINGS: To understand how trisomy 21 causes these neurological abnormalities we investigated changes in gene expression networks combi...

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Detalles Bibliográficos
Autores principales: Hewitt, Chelsee A., Ling, King-Hwa, Merson, Tobias D., Simpson, Ken M., Ritchie, Matthew E., King, Sarah L., Pritchard, Melanie A., Smyth, Gordon K., Thomas, Tim, Scott, Hamish S., Voss, Anne K.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905390/
https://www.ncbi.nlm.nih.gov/pubmed/20661276
http://dx.doi.org/10.1371/journal.pone.0011561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905390/
https://www.ncbi.nlm.nih.gov/pubmed/20661276
http://dx.doi.org/10.1371/journal.pone.0011561

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