Cargando…

Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome

BACKGROUND: Down syndrome (DS) individuals suffer mental retardation with further cognitive decline and early onset Alzheimer's disease. METHODOLOGY/PRINCIPAL FINDINGS: To understand how trisomy 21 causes these neurological abnormalities we investigated changes in gene expression networks combi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hewitt, Chelsee A., Ling, King-Hwa, Merson, Tobias D., Simpson, Ken M., Ritchie, Matthew E., King, Sarah L., Pritchard, Melanie A., Smyth, Gordon K., Thomas, Tim, Scott, Hamish S., Voss, Anne K.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905390/ https://www.ncbi.nlm.nih.gov/pubmed/20661276 http://dx.doi.org/10.1371/journal.pone.0011561

Ejemplares similares

Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome
por: Tan, Kai-Leng, et al.
Publicado: (2014)

Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks
por: Ling, King-Hwa, et al.
Publicado: (2014)

Defects in nerve conduction velocity and different muscle fibre-type specificity contribute to muscle weakness in Ts1Cje Down syndrome mouse model
por: Bala, Usman, et al.
Publicado: (2018)

Phenotype microarrays reveal metabolic dysregulations of neurospheres derived from embryonic Ts1Cje mouse model of Down syndrome
por: Seth, Eryse Amira, et al.
Publicado: (2020)

Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome
por: Duchon, Arnaud, et al.
Publicado: (2011)

Perinatal Natural History of the Ts1Cje Mouse Model of Down Syndrome: Growth Restriction, Early Mortality, Heart Defects, and Delayed Development
por: Ferrés, Millie A., et al.
Publicado: (2016)

Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model
por: Valbuena, Sergio, et al.
Publicado: (2019)

Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome
por: Aziz, Nadine M., et al.
Publicado: (2018)

Hypocellularity in the Murine Model for Down Syndrome Ts65Dn Is Not Affected by Adult Neurogenesis
por: López-Hidalgo, Rosa, et al.
Publicado: (2016)

Luteolin induces hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome
por: Zhou, Wen-Bo, et al.
Publicado: (2019)

Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome
por: Giacomini, Andrea, et al.
Publicado: (2015)

Biphasic cell cycle defect causes impaired neurogenesis in down syndrome
por: Sharma, Vishi, et al.
Publicado: (2022)

Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling
por: Ling, King-Hwa, et al.
Publicado: (2009)

Pathological trajectory in the Ts65Dn model of Down syndrome
por: Tallino, Savannah, et al.
Publicado: (2023)

Synaptic Vesicle Recycling Is Unaffected in the Ts65Dn Mouse Model of Down Syndrome
por: Marland, Jamie R. K., et al.
Publicado: (2016)

Cholinergic Senescence in the Ts65Dn Mouse Model for Down Syndrome
por: Kirstein, Martina, et al.
Publicado: (2022)

Breathing and Oxygen Carrying Capacity in Ts65Dn and Down Syndrome
por: DeRuisseau, Lara R, et al.
Publicado: (2023)

Increased male reproductive success in Ts65Dn “Down syndrome” mice
por: Moore, Clara S., et al.
Publicado: (2010)

Digastric Muscle Phenotypes of the Ts65Dn Mouse Model of Down Syndrome
por: Glass, Tiffany J., et al.
Publicado: (2016)

Perspectives on disrupted-inschizophrenia 1 signaling in neurogenesis
por: Chandran, Jayanth S.
Publicado: (2015)

Galantamine improves olfactory learning in the Ts65Dn mouse model of Down syndrome
por: Simoes de Souza, Fabio M., et al.
Publicado: (2011)

Deleterious Effects of Chronic Folate Deficiency in the Ts65Dn Mouse Model of Down Syndrome
por: Helm, Susan, et al.
Publicado: (2017)

The Adult Ts65Dn Mouse Model of Down Syndrome Shows Altered Swallow Function
por: Glass, Tiffany J., et al.
Publicado: (2019)

Ts66Yah, a mouse model of Down syndrome with improved construct and face validity
por: Duchon, Arnaud, et al.
Publicado: (2022)

Glutamatergic synaptic deficits in the prefrontal cortex of the Ts65Dn mouse model for Down syndrome
por: Thomazeau, Aurore, et al.
Publicado: (2023)

Effects of Neonatal Neural Progenitor Cell Implantation on Adult Neuroanatomy and Cognition in the Ts65Dn Model of Down Syndrome
por: Rachubinski, Angela L., et al.
Publicado: (2012)

Neurogenesis and neuronal differentiation in the postnatal frontal cortex in Down syndrome
por: Utagawa, Emma C., et al.
Publicado: (2022)

Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome
por: Fulton, Sasha L., et al.
Publicado: (2022)

Altered intrinsic and network properties of neocortical neurons in the Ts65Dn mouse model of Down syndrome
por: Cramer, Nathan P., et al.
Publicado: (2015)

Protein Dynamics Associated with Failed and Rescued Learning in the Ts65Dn Mouse Model of Down Syndrome
por: Ahmed, Md. Mahiuddin, et al.
Publicado: (2015)

Phosphoproteomic Alterations of Ionotropic Glutamate Receptors in the Hippocampus of the Ts65Dn Mouse Model of Down Syndrome
por: Gómez de Salazar, Macarena, et al.
Publicado: (2018)

Spatiotemporal development of spinal neuronal and glial populations in the Ts65Dn mouse model of Down syndrome
por: Aziz, Nadine M., et al.
Publicado: (2019)

Signalling pathways contributing to learning and memory deficits in the Ts65Dn mouse model of Down syndrome
por: Freeburn, Aimée, et al.
Publicado: (2021)

TS-MME Workpackages
por: Vuillemin, V
Publicado: (2006)

Synergistic treatment of TS
por: Gurkar, Aditi U., et al.
Publicado: (2017)

Fracture Don’ts
por: Fort, Frank T.
Publicado: (1917)

Crossing the T’s on Norovirus
por: Lee, Sanghyun, et al.
Publicado: (2021)

Disrupted Neurogenesis in Germ-Free Mice: Effects of Age and Sex
por: Scott, Gavin A., et al.
Publicado: (2020)

An adult presentation consistent with PIMS-TS
por: Jones, Imogen, et al.
Publicado: (2020)

Brain Control of Olfaction via Top-down Regulation on Adult Neurogenesis
por: Oboti, Livio, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_92mduc8oe0fa6fnek1b7ar1jv0