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The Impact of Incomplete Linkage Disequilibrium and Genetic Model Choice on the Analysis and Interpretation of Genome-wide Association Studies
When conducting a genetic association study, it has previously been observed that a multiplicative risk model tends to fit better at a disease-associated marker locus than at the ungenotyped causative locus. This suggests that, while overall risk decreases as linkage disequilibrium breaks down, non-...
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| Formato: | Texto |
| Lenguaje: | English |
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Blackwell Publishing Ltd
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905613/ https://www.ncbi.nlm.nih.gov/pubmed/20597907 http://dx.doi.org/10.1111/j.1469-1809.2010.00579.x |