Cargando…

Human single-chain variable fragment that specifically targets arthritic cartilage

OBJECTIVE: To demonstrate that posttranslational modification of type II collagen (CII) by reactive oxygen species (ROS), which are known to be present in inflamed arthritic joints, can give rise to epitopes specific to damaged cartilage in rheumatoid arthritis (RA) and osteoarthritis (OA) and to es...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hughes, Chris, Faurholm, Bjarne, Dell'Accio, Francesco, Manzo, Antonio, Seed, Michael, Eltawil, Noha, Marrelli, Alessandra, Gould, David, Subang, Christina, Al-Kashi, Adam, De Bari, Cosimo, Winyard, Paul, Chernajovsky, Yuti, Nissim, Ahuva
Formato:	Texto
Lenguaje:	English
Publicado:	Wiley Subscription Services, Inc., A Wiley Company 2010
Materias:	Experimental Arthritis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905615/ https://www.ncbi.nlm.nih.gov/pubmed/20131274 http://dx.doi.org/10.1002/art.27346

Ejemplares similares

A novel in vivo murine model of cartilage regeneration. Age and strain-dependent outcome after joint surface injury
por: Eltawil, N.M., et al.
Publicado: (2009)

Molecular response to cartilage injury
por: Dell'Accio, F, et al.
Publicado: (2005)

Targeting of viral interleukin-10 with an antibody fragment specific to damaged arthritic cartilage improves its therapeutic potency
por: Hughes, Chris, et al.
Publicado: (2014)

Gene therapy with an improved doxycycline-regulated plasmid encoding a tumour necrosis factor-alpha inhibitor in experimental arthritis
por: Gould, David, et al.
Publicado: (2007)

Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury
por: Dell'Accio, Francesco, et al.
Publicado: (2006)

In vivo optical imaging of early osteoarthritis using an antibody specific to damaged arthritic cartilage
por: Lim, Ngee Han, et al.
Publicado: (2015)

PPARγ/mTOR signalling: striking the right balance in cartilage homeostasis
por: Dell'Accio, Francesco, et al.
Publicado: (2015)

A novel hybrid promoter responsive to pathophysiological and pharmacological regulation
por: Subang, Maria C., et al.
Publicado: (2011)

Articular Chondroprogenitor Cells Maintain Chondrogenic Potential but Fail to Form a Functional Matrix When Implanted Into Muscles of SCID Mice
por: Marcus, Paula, et al.
Publicado: (2014)

Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody
por: Topping, Louise M., et al.
Publicado: (2020)

WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis
por: Nalesso, Giovanna, et al.
Publicado: (2017)

The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation
por: Inglis, Julia J, et al.
Publicado: (2005)

Effects of APC De-Targeting and GAr Modification on the Duration of Luciferase Expression from Plasmid DNA Delivered to Skeletal Muscle
por: Subang, Maria C., et al.
Publicado: (2015)

A homeostatic function of CXCR2 signalling in articular cartilage
por: Sherwood, Joanna, et al.
Publicado: (2015)

Sortilin Is Upregulated in Osteoarthritis-Dependent Cartilage Calcification and Associated with Cellular Senescence
por: Richter, Elisabeth, et al.
Publicado: (2023)

Novel delivery methods to achieve immunomodulation
por: Gould, David J, et al.
Publicado: (2007)

Inflammatory Cytokines Stabilize SOXC Transcription Factors to Mediate the Transformation of Fibroblast‐Like Synoviocytes in Arthritic Disease
por: Bhattaram, Pallavi, et al.
Publicado: (2018)

PARP-1 inhibition attenuates the inflammatory response in the cartilage of a rat model of osteoarthritis
por: Liu, Zili, et al.
Publicado: (2021)

Culture Expansion in Low-Glucose Conditions Preserves Chondrocyte Differentiation and Enhances Their Subsequent Capacity to Form Cartilage Tissue in Three-Dimensional Culture
por: Heywood, Hannah K., et al.
Publicado: (2014)

Parathyroid hormone (1-34) ameliorates cartilage degeneration and subchondral bone deterioration in collagenase-induced osteoarthritis model in mice
por: Shao, Li-tao, et al.
Publicado: (2020)

Inhibition of established collagen-induced arthritis with a tumour necrosis factor-α inhibitor expressed from a self-contained doxycycline regulated plasmid
por: Gould, David J, et al.
Publicado: (2004)

Knockout of miR-21-5p alleviates cartilage matrix degradation by targeting Gdf5 in temporomandibular joint osteoarthritis
por: Zhang, Aobo, et al.
Publicado: (2020)

Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane
por: De Bari, Cosimo, et al.
Publicado: (2003)

Less mechanical loading attenuates osteoarthritis by reducing cartilage degeneration, subchondral bone remodelling, secondary inflammation, and activation of NLRP3 inflammasome
por: He, Zhennian, et al.
Publicado: (2020)

Gene therapy for arthritis – where do we stand?
por: Chernajovsky, Yuti
Publicado: (2005)

Intra-articular injection of human umbilical cord mesenchymal stem cells ameliorates monosodium iodoacetate-induced osteoarthritis in rats by inhibiting cartilage degradation and inflammation
por: Zhang, Quan, et al.
Publicado: (2021)

MicroRNA-486 promotes a more catabolic phenotype in chondrocyte-like cells by targeting SIRT6: possible involvement in cartilage degradation in osteoarthritis
por: Yang, Jie, et al.
Publicado: (2021)

WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways
por: Nalesso, Giovanna, et al.
Publicado: (2011)

Distinct biological properties of human mesenchymal stem cells from different sources
por: De Bari, C, et al.
Publicado: (2005)

Oxidative post-translational modifications and their involvement in the pathogenesis of autoimmune diseases
por: Ryan, Brent J., et al.
Publicado: (2014)

Targeting the IL-6–Yap–Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis
por: Symons, Rebecca A, et al.
Publicado: (2022)

Regulation of Early Cartilage Destruction in Inflammatory Arthritis by Death Receptor 3
por: Wang, Eddie C Y, et al.
Publicado: (2014)

Finger Joint Cartilage Evaluated by Semiquantitative Ultrasound Score in Patients With Rheumatoid Arthritis
por: Ogura, Takehisa, et al.
Publicado: (2021)

Antibodies to Cartilage Oligomeric Matrix Protein Are Pathogenic in Mice and May Be Clinically Relevant in Rheumatoid Arthritis
por: Ge, Changrong, et al.
Publicado: (2022)

Protective Effects of C-Type Natriuretic Peptide on Linear Growth and Articular Cartilage Integrity in a Mouse Model of Inflammatory Arthritis
por: Bükülmez, Hülya, et al.
Publicado: (2014)

Targeted delivery of cytokine therapy to rheumatoid tissue by a synovial targeting peptide
por: Wythe, Sarah E, et al.
Publicado: (2013)

Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo
por: Eldridge, Suzanne, et al.
Publicado: (2016)

Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis
por: Kania, Karolina, et al.
Publicado: (2020)

Synovial fluid fingerprinting in end-stage knee osteoarthritis: a novel biomarker concept
por: Jayadev, Chethan, et al.
Publicado: (2020)

Promising targets and drugs in rheumatoid arthritis: a module-based and cumulatively scoring approach
por: Li, Xingyan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1rc5bjd74bghn1skcftvku8era