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Elastase-mediated Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein at Discrete Sites within the S2 Domain

Proteolytic priming is a common method of controlling the activation of membrane fusion mediated by viral glycoproteins. The severe acute respiratory syndrome coronavirus spike protein (SARS-CoV S) can be primed by a variety of host cell proteases, with proteolytic cleavage occurring both as the S1/...

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Detalles Bibliográficos
Autores principales:	Belouzard, Sandrine, Madu, Ikenna, Whittaker, Gary R.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906266/ https://www.ncbi.nlm.nih.gov/pubmed/20507992 http://dx.doi.org/10.1074/jbc.M110.103275

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