Activation of endogenous p53 by combined p19Arf gene transfer and nutlin-3 drug treatment modalities in the murine cell lines B16 and C6

BACKGROUND: Reactivation of p53 by either gene transfer or pharmacologic approaches may compensate for loss of p19Arf or excess mdm2 expression, common events in melanoma and glioma. In our previous work, we constructed the pCLPG retroviral vector where transgene expression is controlled by p53 thro...

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Detalles Bibliográficos
Autores principales: Merkel, Christian A, da Silva Soares, Rafael B, de Carvalho, Anna Carolina V, Zanatta, Daniela B, Bajgelman, Marcio C, Fratini, Paula, Costanzi-Strauss, Eugenia, Strauss, Bryan E
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906481/
https://www.ncbi.nlm.nih.gov/pubmed/20569441
http://dx.doi.org/10.1186/1471-2407-10-316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906481/
https://www.ncbi.nlm.nih.gov/pubmed/20569441
http://dx.doi.org/10.1186/1471-2407-10-316

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