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Predicting changes in protein thermostability brought about by single- or multi-site mutations

BACKGROUND: An important aspect of protein design is the ability to predict changes in protein thermostability arising from single- or multi-site mutations. Protein thermostability is reflected in the change in free energy (ΔΔG) of thermal denaturation. RESULTS: We have developed predictive software...

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Detalles Bibliográficos
Autores principales: Tian, Jian, Wu, Ningfeng, Chu, Xiaoyu, Fan, Yunliu
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906492/
https://www.ncbi.nlm.nih.gov/pubmed/20598148
http://dx.doi.org/10.1186/1471-2105-11-370