The BRCT Domain of PARP-1 Is Required for Immunoglobulin Gene Conversion

Genetic variation at immunoglobulin (Ig) gene variable regions in B-cells is created through a multi-step process involving deamination of cytosine bases by activation-induced cytidine deaminase (AID) and their subsequent mutagenic repair. To protect the genome from dangerous, potentially oncogenic...

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Detalles Bibliográficos
Autores principales: Paddock, Marcia N., Buelow, Ben D., Takeda, Shunichi, Scharenberg, Andrew M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907289/
https://www.ncbi.nlm.nih.gov/pubmed/20652015
http://dx.doi.org/10.1371/journal.pbio.1000428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907289/
https://www.ncbi.nlm.nih.gov/pubmed/20652015
http://dx.doi.org/10.1371/journal.pbio.1000428

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