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The BRCT Domain of PARP-1 Is Required for Immunoglobulin Gene Conversion

Genetic variation at immunoglobulin (Ig) gene variable regions in B-cells is created through a multi-step process involving deamination of cytosine bases by activation-induced cytidine deaminase (AID) and their subsequent mutagenic repair. To protect the genome from dangerous, potentially oncogenic...

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Detalles Bibliográficos
Autores principales:	Paddock, Marcia N., Buelow, Ben D., Takeda, Shunichi, Scharenberg, Andrew M.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907289/ https://www.ncbi.nlm.nih.gov/pubmed/20652015 http://dx.doi.org/10.1371/journal.pbio.1000428

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