The Interaction between AID and CIB1 Is Nonessential for Antibody Gene Diversification by Gene Conversion or Class Switch Recombination

Activation-induced deaminase (AID) initiates somatic hypermutation, gene conversion and class switch recombination by deaminating variable and switch region DNA cytidines to uridines. AID is predominantly cytoplasmic and must enter the nuclear compartment to initiate these distinct antibody gene div...

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Detalles Bibliográficos
Autores principales: Demorest, Zachary L., MacDuff, Donna A., Brown, William L., Morham, Scott G., Parise, Leslie V., Harris, Reuben S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907397/
https://www.ncbi.nlm.nih.gov/pubmed/20652029
http://dx.doi.org/10.1371/journal.pone.0011660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907397/
https://www.ncbi.nlm.nih.gov/pubmed/20652029
http://dx.doi.org/10.1371/journal.pone.0011660

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